InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCTS1

Summary

InnateDB Protein

IDBP-84581.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCTS1

Protein Name

malignant T cell amplified sequence 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360367

InnateDB Gene

IDBG-306155 (MCTS1)

Protein Structure

UniProt Annotation

Function

Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up- regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269PubMed:10440924, ECO:0000269PubMed:11709712, ECO:0000269PubMed:12637315, ECO:0000269PubMed:15897892, ECO:0000269PubMed:16322206, ECO:0000269PubMed:16982740, ECO:0000269PubMed:17016429, ECO:0000269PubMed:17416211, ECO:0000269PubMed:20713520, ECO:0000269PubMed:9766643}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11709712, ECO:0000269PubMed:16982740}. Note=Nuclear relocalization after DNA damage.

Disease Associations

Tissue Specificity

Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. {ECO:0000269PubMed:9766643}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0002192	IRES-dependent translational initiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0008284	positive regulation of cell proliferation
GO:0032790	ribosome disassembly
GO:0040008	regulation of growth