InnateDB Protein
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IDBP-84583.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MCTS1
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Protein Name
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malignant T cell amplified sequence 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000360365
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InnateDB Gene
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IDBG-306155 (MCTS1)
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Protein Structure
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Function |
Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up- regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269PubMed:10440924, ECO:0000269PubMed:11709712, ECO:0000269PubMed:12637315, ECO:0000269PubMed:15897892, ECO:0000269PubMed:16322206, ECO:0000269PubMed:16982740, ECO:0000269PubMed:17016429, ECO:0000269PubMed:17416211, ECO:0000269PubMed:20713520, ECO:0000269PubMed:9766643}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11709712, ECO:0000269PubMed:16982740}. Note=Nuclear relocalization after DNA damage.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. {ECO:0000269PubMed:9766643}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002478
PUA domain
IPR004521
Uncharacterised domain CHP00451
IPR015947
PUA-like domain
IPR016437
Translation-associated RNA-binding, predicted
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PFAM |
PF01472
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PRINTS |
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PIRSF |
PIRSF005067
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SMART |
SM00359
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ULC4
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PhosphoSite |
PhosphoSite-Q9ULC4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
28985
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UniGene |
Hs.102696
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RefSeq |
NP_001131026
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HUGO |
HGNC:23357
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OMIM |
300587
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CCDS |
CCDS48160
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HPRD |
06634
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IMGT |
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EMBL |
AB034206
AC011890
AK294834
AK311993
AY364258
BC001013
BC095461
CH471107
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GenPept |
AAH01013
AAH95461
AAQ76817
BAA86055
BAG34931
BAG57943
EAX11874
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