InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCNN1D

Summary

InnateDB Protein

IDBP-84810.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCNN1D

Protein Name

sodium channel, nonvoltage-gated 1, delta

Synonyms

dNaCh; ENaCd; ENaCdelta; SCNED;

Species

Homo sapiens

Ensembl Protein

ENSP00000321594

InnateDB Gene

IDBG-84804 (SCNN1D)

Protein Structure

UniProt Annotation

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19520916}; Multi-pass membrane protein {ECO:0000269PubMed:19520916}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity

Biological Process

GO:0006814	sodium ion transport
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0050896	response to stimulus
GO:0050909	sensory perception of taste
GO:0055085	transmembrane transport