InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRSF3

Summary

InnateDB Protein

IDBP-85000.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF3

Protein Name

serine/arginine-rich splicing factor 3

Synonyms

SFRS3; SRp20;

Species

Homo sapiens

Ensembl Protein

ENSP00000362820

InnateDB Gene

IDBG-84998 (SRSF3)

Protein Structure

UniProt Annotation

Function

May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. RNA-binding is semi-sequence specific. {ECO:0000269PubMed:11336712, ECO:0000269PubMed:18364396}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11336712}. Cytoplasm {ECO:0000269PubMed:11336712}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.

Experimentally validated
Total	124 [view]
Protein-Protein	122 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043274	phospholipase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing