InnateDB Protein
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IDBP-85107.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MMS19
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Protein Name
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MMS19 nucleotide excision repair homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359818
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InnateDB Gene
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IDBG-85105 (MMS19)
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Protein Structure
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Function |
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. {ECO:0000269PubMed:11071939, ECO:0000269PubMed:11328871, ECO:0000269PubMed:20797633, ECO:0000269PubMed:22678361, ECO:0000269PubMed:22678362}.
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Subcellular Localization |
Nucleus. Cytoplasm, cytoskeleton, spindle.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed with higher expression in testis. {ECO:0000269PubMed:11071939, ECO:0000269PubMed:11328871}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
182
[view]
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Protein-Protein |
182
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR016024
Armadillo-type fold
IPR024687
MMS19, C-terminal
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PFAM |
PF12460
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96T76
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PhosphoSite |
PhosphoSite-Q96T76
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64210
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UniGene |
Hs.500721
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RefSeq |
NP_001276334
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HUGO |
HGNC:13824
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OMIM |
614777
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CCDS |
CCDS7464
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HPRD |
17579
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IMGT |
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EMBL |
AF319947
AF357881
AJ306408
AK027710
AK056244
AK056581
AK298995
AK304287
AL355490
AL359388
AY974244
BC002692
BC006575
BC009396
BC080532
BC117129
CH471066
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GenPept |
AAH02692
AAH06575
AAH09396
AAH80532
AAI17130
AAK52668
AAK70402
AAX59033
BAB55315
BAB71223
BAG51657
BAG61084
BAG65145
CAC29239
CAI14189
CAI40770
CAQ08641
CAQ10792
EAW49924
EAW49927
EAW49928
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