Version 5.4
Homo sapiens Protein: C6orf89
Summary
InnateDB Protein IDBP-85136.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C6orf89
Protein Name chromosome 6 open reading frame 89
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000347322
InnateDB Gene IDBG-85130 (C6orf89)
Protein Structure
UniProt Annotation
Function Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells. {ECO:0000269PubMed:21857995, ECO:0000269PubMed:23460338}.
Subcellular Localization Isoform 1: Golgi apparatus membrane; Single- pass type II membrane protein. Midbody.Isoform 2: Cytoplasm. Nucleus, nucleolus. Note=Retained in nucleolar organiser regions (NORs) in mitotic cells.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0042060 wound healing
GO:0045787 positive regulation of cell cycle
GO:0050673 epithelial cell proliferation
Cellular Component
GO:0000139 Golgi membrane
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030496 midbody
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UWU4
PhosphoSite PhosphoSite-Q6UWU4
TrEMBL Q5TDC5
UniProt Splice Variant
Entrez Gene 221477
UniGene Hs.625324
RefSeq NP_689947
HUGO HGNC:21114
OMIM
CCDS CCDS4827
HPRD 12905
IMGT
EMBL AK172780 AK300351 AL122034 AY358637 BC023605 BC095423 BC105946 BC105947 BC107489 BX538108 CH471081 FR832871 FR832872
GenPept AAH23605 AAH95423 AAI05947 AAI05948 AAI07490 AAQ89000 BAD18761 BAG62093 CAD98021 CAI23297 CAI23299 CCA30148 CCA30149 EAX03919 EAX03920 EAX03922

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca