Version 5.4
Homo sapiens Protein: PI16
Summary
InnateDB Protein IDBP-85163.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PI16
Protein Name peptidase inhibitor 16
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362778
InnateDB Gene IDBG-85161 (PI16)
Protein Structure
UniProt Annotation
Function Putative serine protease inhibitor. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in prostate, testis, ovary and intestine. Concentrates in prostate cancer patient's sera. {ECO:0000269PubMed:15344909, ECO:0000269PubMed:17062675}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
Cellular Component
GO:0005615 extracellular space
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001283 Cysteine-rich secretory protein, allergen V5/Tpx-1-related
IPR014044 CAP domain
PFAM PF00188
PRINTS PR00837
PIRSF PIRSF038921
SMART SM00198
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UXB8
PhosphoSite PhosphoSite-Q6UXB8
TrEMBL B4DXZ3
UniProt Splice Variant
Entrez Gene 221476
UniGene Hs.25391
RefSeq NP_699201
HUGO HGNC:21245
OMIM
CCDS CCDS34440
HPRD
IMGT
EMBL AK075470 AK124589 AK302193 AL122034 AY358422 BC022399 BC035634
GenPept AAH22399 AAH35634 AAQ88788 BAC11640 BAC85892 BAG63555 CAI23302

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca