InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLCO4A1

Summary

InnateDB Protein

IDBP-85273.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLCO4A1

Protein Name

solute carrier organic anion transporter family, member 4A1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000359538

InnateDB Gene

IDBG-85265 (SLCO4A1)

Protein Structure

UniProt Annotation

Function

Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous, with the exception of spleen and leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0043252	sodium-independent organic anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002350 Kazal domain
IPR004156 Organic anion transporter polypeptide OATP
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00050
PF07648
PF03137
PF07690

PRINTS

PIRSF

SMART

SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96BD0