Version 5.4
Homo sapiens Protein: OGFR
Summary
InnateDB Protein IDBP-85357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OGFR
Protein Name opioid growth factor receptor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000290291
InnateDB Gene IDBG-85351 (OGFR)
Protein Structure
UniProt Annotation
Function Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=The OGF/OGFR complex is probably translocated to the nucleus.
Disease Associations
Tissue Specificity Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004985 opioid receptor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0038003 opioid receptor signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR006757 Opioid growth factor receptor (OGFr) conserved domain
IPR006770 Opioid growth factor receptor repeat
PFAM PF04664
PF04680
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZT2
PhosphoSite PhosphoSite-Q9NZT2
TrEMBL Q4VXW3
UniProt Splice Variant
Entrez Gene 11054
UniGene
RefSeq NP_031372
HUGO HGNC:15768
OMIM 606459
CCDS CCDS13504
HPRD 08404
IMGT
EMBL AF109134 AF112980 AF172451 AF172452 AF172453 AK024485 AL035669 BC014137
GenPept AAD03737 AAD03745 AAF64404 AAF64405 AAF64406 AAH14137 BAB15775 CAC28882 CAI95763

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca