InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZDHHC2

Summary

InnateDB Protein

IDBP-8537.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZDHHC2

Protein Name

zinc finger, DHHC-type containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262096

InnateDB Gene

IDBG-8535 (ZDHHC2)

Protein Structure

UniProt Annotation

Function

Palmitoyltransferase specific for GAP43 and DLG4/PSD95. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Note=Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer.

Tissue Specificity

Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis. {ECO:0000269PubMed:10918388}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0008270	zinc ion binding
GO:0016409	palmitoyltransferase activity
GO:0019706	protein-cysteine S-palmitoyltransferase activity

Biological Process

GO:0007275	multicellular organismal development
GO:0018345	protein palmitoylation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0055038	recycling endosome membrane