InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PI4K2A

Summary

InnateDB Protein

IDBP-85652.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PI4K2A

Protein Name

phosphatidylinositol 4-kinase type 2 alpha

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000359665

InnateDB Gene

IDBG-85582 (PI4K2A)

Protein Structure

UniProt Annotation

Function

Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Membrane raft. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Mitochondrion {ECO:0000250}. Endosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localized in neuronal cell body. Transported from neuronal cell body to neuron projections in a BLOC-1- and AP-3-complexes-dependent manner. Enriched in neurite tips and neuron projections in a BLOC- 1- and AP-3-complexes-dependent manner (By similarity). Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine. {ECO:0000269PubMed:11279162}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004430	1-phosphatidylinositol 4-kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0032403	protein complex binding
GO:0035651	AP-3 adaptor complex binding

Biological Process

GO:0002561	basophil degranulation
GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046854	phosphatidylinositol phosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030054	cell junction
GO:0030425	dendrite
GO:0030672	synaptic vesicle membrane
GO:0031083	BLOC-1 complex
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane
GO:0035838	growing cell tip
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0044231	host cell presynaptic membrane
GO:0045121	membrane raft
GO:0070382	exocytic vesicle