Version 5.4
Homo sapiens Protein: SASH3
Summary
InnateDB Protein IDBP-85668.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SASH3
Protein Name SAM and SH3 domain containing 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349359
InnateDB Gene IDBG-85664 (SASH3)
Protein Structure
UniProt Annotation
Function May function as a signaling adapter protein in lymphocytes. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002639 positive regulation of immunoglobulin production
GO:0002726 positive regulation of T cell cytokine production
GO:0002821 positive regulation of adaptive immune response
GO:0030890 positive regulation of B cell proliferation
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042102 positive regulation of T cell proliferation
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0046622 positive regulation of organ growth
GO:0048873 homeostasis of number of cells within a tissue
GO:0051251 positive regulation of lymphocyte activation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR011511 Variant SH3 domain
IPR013761 Sterile alpha motif/pointed domain
IPR021090 SAM/SH3 domain-containing
IPR021129 Sterile alpha motif, type 1
PFAM PF00018
PF14604
PF07647
PF07653
PF12485
PF00536
PRINTS PR00452
PIRSF
SMART SM00326
SM00454
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75995
PhosphoSite PhosphoSite-O75995
TrEMBL
UniProt Splice Variant
Entrez Gene 54440
UniGene Hs.61469
RefSeq NP_061863
HUGO HGNC:15975
OMIM 300441
CCDS CCDS14614
HPRD 02342
IMGT
EMBL AK292023 AL023653 AL049683 BC051881 CH471107
GenPept AAH51881 BAF84712 CAA19221 CAB41255 EAX11826

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca