Version 5.4
Homo sapiens Protein: YTHDF1
Summary
InnateDB Protein IDBP-85810.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YTHDF1
Protein Name YTH domain family, member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359364
InnateDB Gene IDBG-85808 (YTHDF1)
Protein Structure
UniProt Annotation
Function Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. {ECO:0000269PubMed:24284625}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
GO:1990247 N6-methyladenosine-containing RNA binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR007275 YTH domain
PFAM PF04146
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BYJ9
PhosphoSite PhosphoSite-Q9BYJ9
TrEMBL F8W840
UniProt Splice Variant
Entrez Gene 54915
UniGene Hs.742274
RefSeq NP_060268
HUGO HGNC:15867
OMIM
CCDS CCDS13511
HPRD 11691
IMGT
EMBL AB055518 AK000398 AL096828 AL834366 BC003681 BC016920 BC025264 BC050284
GenPept AAH03681 AAH16920 AAH25264 AAH50284 BAA91138 BAB62751 CAC09391 CAD39029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca