InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLO1

Summary

InnateDB Protein

IDBP-85870.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLO1

Protein Name

glyoxalase I

Synonyms

GLOD1; GLYI; HEL-S-74;

Species

Homo sapiens

Ensembl Protein

ENSP00000362463

InnateDB Gene

IDBG-85868 (GLO1)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis. {ECO:0000269PubMed:19199007, ECO:0000269PubMed:23122816, ECO:0000269PubMed:9705294}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004462	lactoylglutathione lyase activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006749	glutathione metabolic process
GO:0009438	methylglyoxal metabolic process
GO:0030316	osteoclast differentiation
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
IPR004361 Glyoxalase I
IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

PFAM

PF00903

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q04760

PhosphoSite