Version 5.4
Homo sapiens Protein: LOXL4
Summary
InnateDB Protein IDBP-85884.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LOXL4
Protein Name lysyl oxidase-like 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000260702
InnateDB Gene IDBG-85882 (LOXL4)
Protein Structure
UniProt Annotation
Function May modulate the formation of a collagenous extracellular matrix.
Subcellular Localization Secreted, extracellular space {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004720 protein-lysine 6-oxidase activity
GO:0005044 scavenger receptor activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001190 SRCR domain
IPR001695 Lysyl oxidase
IPR017448 SRCR-like domain
PFAM PF00530
PF01186
PRINTS PR00258
PR00074
PIRSF
SMART SM00202
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JB6
PhosphoSite PhosphoSite-Q96JB6
TrEMBL
UniProt Splice Variant
Entrez Gene 84171
UniGene Hs.306814
RefSeq NP_115587
HUGO HGNC:17171
OMIM 607318
CCDS CCDS7473
HPRD 09538
IMGT
EMBL AF338441 AF395336 AK025542 AK172781 AL139241 AY036093 BC007522 BC013153 CH471066
GenPept AAH07522 AAH13153 AAK64186 AAK71934 AAL27543 BAB15167 BAD18762 CAH72819 EAW49886

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca