InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC25A14

Summary

InnateDB Protein

IDBP-86098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A14

Protein Name

solute carrier family 25 (mitochondrial carrier, brain), member 14

Synonyms

BMCP1; UCP5;

Species

Homo sapiens

Ensembl Protein

ENSP00000218197

InnateDB Gene

IDBG-86094 (SLC25A14)

Protein Structure

UniProt Annotation

Function

Participates in the mitochondrial proton leak measured in brain mitochondria.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly expressed in brain. Some expression in testis and pituitary. {ECO:0000269PubMed:10928996}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006810	transport
GO:0006839	mitochondrial transport
GO:0009060	aerobic respiration

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002030 Mitochondrial brown fat uncoupling protein
IPR002067 Mitochondrial carrier protein
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00153

PRINTS

PR00784
PR00926

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95258