InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCC2

Summary

InnateDB Protein

IDBP-86123.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCC2

Protein Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Synonyms

ABC30; CMOAT; cMRP; DJS; MRP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000359478

InnateDB Gene

IDBG-86121 (ABCC2)

Protein Structure

UniProt Annotation

Function

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:11093739}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441, ECO:0000269PubMed:11093739}.

Disease Associations

Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. {ECO:0000269PubMed:10053008, ECO:0000269PubMed:10464142, ECO:0000269PubMed:11266082, ECO:0000269PubMed:11477083, ECO:0000269PubMed:9425227}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	47 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008514	organic anion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0019904	protein domain specific binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0006979	response to oxidative stress
GO:0009408	response to heat
GO:0015732	prostaglandin transport
GO:0030644	cellular chloride ion homeostasis
GO:0031427	response to methotrexate
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0046685	response to arsenic-containing substance
GO:0055085	transmembrane transport
GO:0070327	thyroid hormone transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0046581	intercellular canaliculus

Protein Structure and Domains

PDB ID

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR005292 Multi drug resistance-associated protein
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92887