InnateDB Protein
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IDBP-86138.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C1orf86
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Protein Name
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chromosome 1 open reading frame 86
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367808
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InnateDB Gene
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IDBG-86132 (C1orf86)
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Protein Structure
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Function |
Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. {ECO:0000269PubMed:22266823, ECO:0000269PubMed:22343915, ECO:0000269PubMed:22396592, ECO:0000269PubMed:22705371}.
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Subcellular Localization |
Nucleus. Chromosome. Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6NZ36
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PhosphoSite |
PhosphoSite-Q6NZ36
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
199990
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UniGene |
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RefSeq |
NP_872339
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HUGO |
HGNC:26428
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OMIM |
615183
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CCDS |
CCDS38
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HPRD |
08707
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IMGT |
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EMBL |
AF461903
AK055593
AK126870
AL590822
BC066360
BC078145
BC103992
CH471183
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GenPept |
AAH66360
AAI03993
AAQ04817
BAB70965
BAC86730
EAW56125
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