InnateDB Protein
|
IDBP-86242.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ENOX2
|
Protein Name
|
ecto-NOX disulfide-thiol exchanger 2
|
Synonyms
|
APK1; COVA1; tNOX;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000359973
|
InnateDB Gene
|
IDBG-86240 (ENOX2)
|
Protein Structure
|
|
Function |
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269PubMed:12356293, ECO:0000269PubMed:9932650}.
|
Subcellular Localization |
Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.
|
Disease Associations |
|
Tissue Specificity |
Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
|
Protein-Protein |
9
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000504
RNA recognition motif domain
|
PFAM |
PF00076
|
PRINTS |
|
PIRSF |
|
SMART |
SM00360
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q16206
|
PhosphoSite |
PhosphoSite-Q16206
|
TrEMBL |
B1AKF7
|
UniProt Splice Variant |
|
Entrez Gene |
10495
|
UniGene |
Hs.171458
|
RefSeq |
NP_001268665
|
HUGO |
HGNC:2259
|
OMIM |
300282
|
CCDS |
CCDS14627
|
HPRD |
02234
|
IMGT |
|
EMBL |
AF207881
AK000353
AK289812
AK289837
AL022153
AL049565
AL049733
AL133207
AL591908
BC019254
BC140874
CH471107
S72904
Z80232
|
GenPept |
AAB30428
AAF20934
AAH19254
AAI40875
BAF82501
BAF82526
CAB61581
CAH71675
CAH71676
CAI43113
CAI43114
EAX11796
EAX11797
|
|
|