Version 5.4
Homo sapiens Protein: CPN1
Summary
InnateDB Protein IDBP-86251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPN1
Protein Name carboxypeptidase N, polypeptide 1
Synonyms CPN; SCPN;
Species Homo sapiens
Ensembl Protein ENSP00000359446
InnateDB Gene IDBG-86249 (CPN1)
Protein Structure
UniProt Annotation
Function Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
Subcellular Localization Secreted, extracellular space.
Disease Associations Carboxypeptidase N deficiency (CPND) [MIM:212070]: Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or asthma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. {ECO:0000269PubMed:12560874}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Synthesized in the liver and secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0010815 bradykinin catabolic process
GO:0051384 response to glucocorticoid
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000834 Peptidase M14, carboxypeptidase A
IPR008969 Carboxypeptidase-like, regulatory domain
IPR021259 Protein of unknown function DUF2817
PFAM PF00246
PF10994
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P15169
PhosphoSite PhosphoSite-P15169
TrEMBL B1AP58
UniProt Splice Variant
Entrez Gene 1369
UniGene Hs.2246
RefSeq NP_001299
HUGO HGNC:2312
OMIM 603103
CCDS CCDS7486
HPRD 09120
IMGT
EMBL AK313972 AL441886 BC027897 CH471066 X14329
GenPept AAH27897 BAG36687 CAA32507 EAW49848

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca