InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF14

Summary

InnateDB Protein

IDBP-86401.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF14

Protein Name

tumor necrosis factor receptor superfamily, member 14

Synonyms

ATAR; CD270; HVEA; HVEM; LIGHTR; TR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000347948

InnateDB Gene

IDBG-86399 (TNFRSF14)

Protein Structure

UniProt Annotation

Function

Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. {ECO:0000269PubMed:8898196}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed, with the highest expression in lung, spleen and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0002741	positive regulation of cytokine secretion involved in immune response
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0009615	response to virus
GO:0016032	viral process
GO:0031295	T cell costimulation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0046642	negative regulation of alpha-beta T cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:2000406	positive regulation of T cell migration