Homo sapiens Protein: UNC5CL
Summary
InnateDB Protein IDBP-86453.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC5CL
Protein Name unc-5 homolog C (C. elegans)-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362258
InnateDB Gene IDBG-86449 (UNC5CL)
Protein Structure
UniProt Annotation
Function Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets. {ECO:0000269PubMed:14769797}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:14769797}.
Disease Associations
Tissue Specificity Expressed in pancreas, liver and kidney. {ECO:0000269PubMed:14769797}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007165 signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0046330 positive regulation of JNK cascade
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000488 Death domain
IPR000906 ZU5 domain
IPR011029 Death-like domain
PFAM PF00531
PF00791
PRINTS
PIRSF
SMART SM00005
SM00218
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IV45
PhosphoSite PhosphoSite-Q8IV45
TrEMBL H8YHX0
UniProt Splice Variant
Entrez Gene 222643
UniGene Hs.158357
RefSeq
HUGO HGNC:21203
OMIM
CCDS CCDS4847
HPRD 09844
IMGT
EMBL AL031778 AY510109 BC035284 CH471081 JF681947
GenPept AAH35284 AAS80165 AEB96256 CAI20283 EAX04007