Version 5.4
Homo sapiens Protein: APOBEC2
Summary
InnateDB Protein IDBP-86464.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOBEC2
Protein Name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
Synonyms ARCD1; ARP1;
Species Homo sapiens
Ensembl Protein ENSP00000244669
InnateDB Gene IDBG-86462 (APOBEC2)
Protein Structure
UniProt Annotation
Function Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269PubMed:21496894}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed exclusively in heart and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Biological Process
GO:0006397 mRNA processing
GO:0009972 cytidine deamination
GO:0016556 mRNA modification
GO:0080111 DNA demethylation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR007904 APOBEC-like, C-terminal
IPR013158 APOBEC-like, N-terminal
IPR016193 Cytidine deaminase-like
PFAM PF05240
PF08210
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y235
PhosphoSite PhosphoSite-Q9Y235
TrEMBL
UniProt Splice Variant
Entrez Gene 10930
UniGene Hs.659926
RefSeq NP_006780
HUGO HGNC:605
OMIM 604797
CCDS CCDS4848
HPRD 07268
IMGT
EMBL AF161698 AK223461 AK313288 AL031778 BC047767 BC069688 BC069764 CH471081
GenPept AAD45360 AAH47767 AAH69688 AAH69764 BAD97181 BAG36096 CAB44740 EAX04009

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca