InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TREM2

Summary

InnateDB Protein

IDBP-86568.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TREM2

Protein Name

triggering receptor expressed on myeloid cells 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362214

InnateDB Gene

IDBG-86566 (TREM2)

Protein Structure

UniProt Annotation

Function

May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. {ECO:0000269PubMed:10799849}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.

Disease Associations

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]: Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. {ECO:0000269PubMed:12080485}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord. {ECO:0000269PubMed:10799849, ECO:0000269PubMed:12080485}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0097110	scaffold protein binding

Biological Process

GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0006959	humoral immune response
GO:0007411	axon guidance
GO:0045087	innate immune response (InnateDB)
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0097028	dendritic cell differentiation
GO:1903078	positive regulation of protein localization to plasma membrane
GO:1903082	positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:2000350	positive regulation of CD40 signaling pathway