Version 5.4
Homo sapiens Protein: ST6GALNAC4
Summary
InnateDB Protein IDBP-86928.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST6GALNAC4
Protein Name ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000336733
InnateDB Gene IDBG-86926 (ST6GALNAC4)
Protein Structure
UniProt Annotation
Function Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008373 sialyltransferase activity
GO:0047290 (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0006664 glycolipid metabolic process
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001675 Glycosyl transferase, family 29
PFAM PF00777
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H4F1
PhosphoSite PhosphoSite-Q9H4F1
TrEMBL A8K7N4
UniProt Splice Variant
Entrez Gene 27090
UniGene Hs.3972
RefSeq NP_778204
HUGO HGNC:17846
OMIM 606378
CCDS CCDS6883
HPRD 05902
IMGT
EMBL AB035172 AF127142 AJ271734 AK000600 AK292049 AL157935 BC036705 CH471090 Y17460 Y17461
GenPept AAF00102 AAH36705 BAA87034 BAA91281 BAF84738 CAB44353 CAB44354 CAC07404 CAI12613 EAW87717 EAW87718 EAW87719 EAW87720

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca