Version 5.4
Homo sapiens Protein: PIP5KL1
Summary
InnateDB Protein IDBP-87024.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIP5KL1
Protein Name phosphatidylinositol-4-phosphate 5-kinase-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000300432
InnateDB Gene IDBG-87022 (PIP5KL1)
Protein Structure
UniProt Annotation
Function May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. {ECO:0000250}.
Subcellular Localization Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016307 phosphatidylinositol phosphate kinase activity
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
Biological Process
GO:0046488 phosphatidylinositol metabolic process
GO:0046854 phosphatidylinositol phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
PFAM PF01504
PRINTS
PIRSF
SMART SM00330
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5T9C9
PhosphoSite PhosphoSite-Q5T9C9
TrEMBL
UniProt Splice Variant
Entrez Gene 138429
UniGene Hs.734928
RefSeq NP_775763
HUGO HGNC:28711
OMIM 612865
CCDS CCDS6885
HPRD 15139
IMGT
EMBL AL157935 BC042184
GenPept AAH42184 CAI12614 CAM14148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca