InnateDB Protein
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IDBP-87036.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TLX1
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Protein Name
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T-cell leukemia homeobox 1
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Synonyms
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HOX11; TCL3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359215
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InnateDB Gene
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IDBG-87034 (TLX1)
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Protein Structure
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Function |
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
|
Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
IPR020479
Homeodomain, metazoa
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PFAM |
PF00046
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PRINTS |
PR00024
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
P31314
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PhosphoSite |
PhosphoSite-P31314
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3195
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UniGene |
|
RefSeq |
NP_005512
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HUGO |
HGNC:5056
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OMIM |
186770
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CCDS |
CCDS7510
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HPRD |
01728
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IMGT |
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EMBL |
AF067443
AJ009794
AL357395
BC130530
CH471066
M62626
M75952
S38742
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GenPept |
AAA36719
AAA58662
AAB19293
AAG10096
AAI30531
CAA08834
CAH72448
EAW49778
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