InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTGES2

Summary

InnateDB Protein

IDBP-87285.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGES2

Protein Name

prostaglandin E synthase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000345341

InnateDB Gene

IDBG-87283 (PTGES2)

Protein Structure

UniProt Annotation

Function

Dual function enzyme which exhibits both isomerase and lyase activities. Its catalytic activity is altered by the presence or absence of the cofactors glutathione (GSH) and heme. The GSH-heme complex-bound enzyme (mPGES-2h) acts as a lyase and catalyzes the degradation of prostaglandin E2 H2 (PGH2) to 12(S)- hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) while the GSH-heme complex-free enzyme (mPGES-2) acts as an isomerase and catalyzes the isomerization of PGH2 into the more stable prostaglandin E2 (PGE2) form (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:12835322}; Single-pass membrane protein {ECO:0000269PubMed:12835322}.Prostaglandin E synthase 2 truncated form: Cytoplasm, perinuclear region. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer. {ECO:0000269PubMed:11866447}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0016829	lyase activity
GO:0020037	heme binding
GO:0043295	glutathione binding
GO:0050220	prostaglandin-E synthase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045454	cell redox homeostasis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046903	secretion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002109 Glutaredoxin
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM