InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD40LG

Summary

InnateDB Protein

IDBP-87655.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD40LG

Protein Name

CD40 ligand

Synonyms

CD154; CD40L; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000359663

InnateDB Gene

IDBG-87653 (CD40LG)

Protein Structure

UniProt Annotation

Function

Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. {ECO:0000269PubMed:15193700}.Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000269PubMed:15193700}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein.CD40 ligand, soluble form: Secreted.

Disease Associations

X-linked immunodeficiency with hyper-IgM 1 (HIGM1) [MIM:308230]: Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. {ECO:0000269PubMed:7532185, ECO:0000269PubMed:7678782, ECO:0000269PubMed:7679206, ECO:0000269PubMed:7679801, ECO:0000269PubMed:7717401, ECO:0000269PubMed:8094231, ECO:0000269PubMed:8550833, ECO:0000269PubMed:8889581, ECO:0000269PubMed:9150729, ECO:0000269PubMed:9746782}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Specifically expressed on activated CD4+ T- lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	13 [view]
Protein-DNA	8 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005174	CD40 receptor binding
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007159	leukocyte cell-cell adhesion
GO:0030168	platelet activation
GO:0030183	B cell differentiation
GO:0032735	positive regulation of interleukin-12 production
GO:0042100	B cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0045190	isotype switching
GO:0048305	immunoglobulin secretion
GO:0050776	regulation of immune response
GO:0051023	regulation of immunoglobulin secretion
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane