InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPBWR2

Summary

InnateDB Protein

IDBP-87890.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPBWR2

Protein Name

neuropeptides B/W receptor 2

Synonyms

GPR8;

Species

Homo sapiens

Ensembl Protein

ENSP00000358783

InnateDB Gene

IDBG-87888 (NPBWR2)

Protein Structure

UniProt Annotation

Function

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected at high levels in caudate nucleus, hyppocampus and amygdala; at moderate levels in the adult brain, thalamus, parietal cortex, pituitary gland, adrenal gland and lymph nodes. {ECO:0000269PubMed:12401809}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004985	opioid receptor activity
GO:0005515	protein binding
GO:0008188	neuropeptide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0038003	opioid receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000586 Somatostatin receptor family
IPR000611 Neuropeptide Y receptor family
IPR001418 Opioid receptor
IPR009150 Neuropeptide B/W receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)

PFAM

PF00001
PF10320
PF10323

PRINTS

PR00237
PR00246
PR01012
PR00384
PR01855

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48146