InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYT1

Summary

InnateDB Protein

IDBP-87904.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYT1

Protein Name

myelin transcription factor 1

Synonyms

C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2HC4A;

Species

Homo sapiens

Ensembl Protein

ENSP00000327465

InnateDB Gene

IDBG-87900 (MYT1)

Protein Structure

UniProt Annotation

Function

Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269PubMed:14962745}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes. {ECO:0000269PubMed:8530187}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001158	enhancer sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0030154	cell differentiation