Version 5.4
Homo sapiens Protein: COQ4
Summary
InnateDB Protein IDBP-87910.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COQ4
Protein Name coenzyme Q4 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000300452
InnateDB Gene IDBG-87908 (COQ4)
Protein Structure
UniProt Annotation
Function Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. {ECO:0000255HAMAP- Rule:MF_03111, ECO:0000269PubMed:18474229}.
Subcellular Localization Isoform 1: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Disease Associations
Tissue Specificity Expressed ubiquitously, but at high levels in liver, lung and pancreas. {ECO:0000269PubMed:18474229}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006744 ubiquinone biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Protein Structure and Domains
PDB ID
InterPro IPR007715 Ubiquinone biosynthesis protein Coq4
PFAM PF05019
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y3A0
PhosphoSite PhosphoSite-Q9Y3A0
TrEMBL
UniProt Splice Variant
Entrez Gene 51117
UniGene Hs.98541
RefSeq NP_057119
HUGO HGNC:19693
OMIM 612898
CCDS CCDS6898
HPRD 16741
IMGT
EMBL AF151850 AK313650 AL359091 BC011895 CH471090 EU216419 EU216420 EU216421 EU216422 EU216423
GenPept AAD34087 AAH11895 ABW91141 ABW91142 ABW91143 ABW91144 ABW91145 BAG36405 CAI13487 EAW87776

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca