Version 5.4
Homo sapiens Protein: NOL9
Summary
InnateDB Protein IDBP-87915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOL9
Protein Name nucleolar protein 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366934
InnateDB Gene IDBG-87913 (NOL9)
Protein Structure
UniProt Annotation
Function Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA. {ECO:0000269PubMed:21063389}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:21063389}. Note=Colocalizes with pre-60S rRNP particles.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0051731 polynucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0000460 maturation of 5.8S rRNA
GO:0016310 phosphorylation
Cellular Component
GO:0005730 nucleolus
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR010655 Pre-mRNA cleavage complex II Clp1
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029007 MobB-type P-loop domain
PFAM PF06807
PF03205
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5SY16
PhosphoSite PhosphoSite-Q5SY16
TrEMBL
UniProt Splice Variant
Entrez Gene 79707
UniGene Hs.59425
RefSeq NP_078930
HUGO HGNC:26265
OMIM
CCDS CCDS80
HPRD 08667
IMGT
EMBL AK026976 AK289653 AL591866 BC009257 BC012439 BC063639 BC094836 BC105095 BC110849 BC112278
GenPept AAH09257 AAH12439 AAH63639 AAH94836 AAI05096 AAI10850 AAI12279 BAB15611 BAF82342 CAI16071

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca