InnateDB Protein
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IDBP-87988.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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URM1
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Protein Name
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ubiquitin related modifier 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000361941
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InnateDB Gene
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IDBG-87984 (URM1)
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Protein Structure
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Function |
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. {ECO:0000255HAMAP- Rule:MF_03048, ECO:0000269PubMed:19017811, ECO:0000269PubMed:21209336}.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
38
[view]
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Protein-Protein |
38
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR015221
Ubiquitin-related modifier 1
IPR016155
Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp
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PFAM |
PF09138
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PRINTS |
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PIRSF |
PIRSF037379
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
81605
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UniGene |
Hs.495229
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RefSeq |
NP_001252511
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HUGO |
HGNC:28378
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OMIM |
612693
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CCDS |
CCDS59148
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HPRD |
12976
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IMGT |
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EMBL |
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GenPept |
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