Version 5.4
Homo sapiens Protein: THAP3
Summary
InnateDB Protein IDBP-88070.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THAP3
Protein Name THAP domain containing, apoptosis associated protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000054650
InnateDB Gene IDBG-88068 (THAP3)
Protein Structure
UniProt Annotation
Function Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. {ECO:0000269PubMed:20200153}.
Subcellular Localization
Disease Associations
Tissue Specificity Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver. {ECO:0000269PubMed:20200153}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR006612 Zinc finger, C2CH-type
PFAM PF05485
PRINTS
PIRSF
SMART SM00692
SM00980
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WTV1
PhosphoSite PhosphoSite-Q8WTV1
TrEMBL
UniProt Splice Variant
Entrez Gene 90326
UniGene Hs.689006
RefSeq NP_001182682
HUGO HGNC:20855
OMIM 612532
CCDS CCDS55572
HPRD 18178
IMGT
EMBL AK096217 AL031447 BC005114 BC092427
GenPept AAH05114 AAH92427 BAC04727 CAI19468 CAI19469 CAI19470

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca