InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM8

Summary

InnateDB Protein

IDBP-88138.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM8

Protein Name

tripartite motif containing 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000302120

InnateDB Gene

IDBG-88134 (TRIM8)

Protein Structure

UniProt Annotation

Function

Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032897	negative regulation of viral transcription
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0046597	negative regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1902187	negative regulation of viral release from host cell