InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLK2

Summary

InnateDB Protein

IDBP-88160.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLK2

Protein Name

delta-like 2 homolog (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000349893

InnateDB Gene

IDBG-88152 (DLK2)

Protein Structure

UniProt Annotation

Function

Regulates adipogenesis. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0045598	regulation of fat cell differentiation
GO:0045746	negative regulation of Notch signaling pathway

Cellular Component

GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF07645
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6UY11

PhosphoSite

PhosphoSite-

TrEMBL

Q5T3U0

UniProt Splice Variant

Entrez Gene

65989

UniGene

Hs.337251

RefSeq

NP_996262

HUGO

HGNC:21113

OMIM

CCDS

CCDS4897

HPRD

16855

IMGT

EMBL

AK055380 AL359813 AY358126 BC000230 BC006425 BC110320 CH471081

GenPept

AAH00230 AAH06425 AAI10321 AAQ88493 BAG51509 CAI23224 EAX04186 EAX04191