Version 5.4
Homo sapiens Protein: SFXN2
Summary
InnateDB Protein IDBP-88176.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFXN2
Protein Name sideroflexin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000358909
InnateDB Gene IDBG-88174 (SFXN2)
Protein Structure
UniProt Annotation
Function Potential iron transporter.
Subcellular Localization Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed, highest levels in kidney, liver, and pancreas. {ECO:0000269PubMed:12670026}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008324 cation transmembrane transporter activity
Biological Process
GO:0006812 cation transport
GO:0055072 iron ion homeostasis
GO:0055085 transmembrane transport
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004686 Tricarboxylate/iron carrier
PFAM PF03820
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96NB2
PhosphoSite PhosphoSite-Q96NB2
TrEMBL R4GNB8
UniProt Splice Variant
Entrez Gene 118980
UniGene Hs.44070
RefSeq NP_849189
HUGO HGNC:16086
OMIM 615570
CCDS CCDS7539
HPRD 18045
IMGT
EMBL AF462052 AK055711 AL391121 BC022091 CH471066
GenPept AAH22091 AAM09645 BAB70993 EAW49675 EAW49677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca