Version 5.4
Homo sapiens Protein: MAGEC2
Summary
InnateDB Protein IDBP-88267.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGEC2
Protein Name melanoma antigen family C, 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354660
InnateDB Gene IDBG-88265 (MAGEC2)
Protein Structure
UniProt Annotation
Function Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. {ECO:0000269PubMed:20864041}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12920247}. Nucleus {ECO:0000269PubMed:12920247}. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.
Disease Associations
Tissue Specificity Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non- small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. {ECO:0000269PubMed:12097419, ECO:0000269PubMed:12920247}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0044257 cellular protein catabolic process
GO:0051443 positive regulation of ubiquitin-protein transferase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002190 MAGE protein
IPR021072 Melanoma associated antigen, MAGE, N-terminal
PFAM PF01454
PF12440
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBF1
PhosphoSite PhosphoSite-Q9UBF1
TrEMBL
UniProt Splice Variant
Entrez Gene 51438
UniGene Hs.123536
RefSeq NP_057333
HUGO HGNC:13574
OMIM 300468
CCDS CCDS14678
HPRD 06632
IMGT
EMBL AF116194 AF116195 AF151378 AF196482 AF196483 AF239802 AL031073 BC005891 BC013318
GenPept AAF07210 AAF07211 AAF34816 AAF34817 AAF36533 AAH05891 AAH13318 AAK15073 CAI42324

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca