InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF9

Summary

InnateDB Protein

IDBP-88270.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF9

Protein Name

tumor necrosis factor receptor superfamily, member 9

Synonyms

4-1BB; CD137; CDw137; ILA;

Species

Homo sapiens

Ensembl Protein

ENSP00000366729

InnateDB Gene

IDBG-88268 (TNFRSF9)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed on the surface of activated T-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001368 TNFR/NGFR cysteine-rich region
IPR020413 Tumour necrosis factor receptor 9

PFAM

PF00020

PRINTS

PR01924

PIRSF

SMART

SM00208

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q07011

PhosphoSite

PhosphoSite-Q07011

TrEMBL

UniProt Splice Variant

Entrez Gene

3604

UniGene

Hs.86447

RefSeq

XP_006710681

HUGO

HGNC:11924

OMIM

602250

CCDS

CCDS92

HPRD

03767

IMGT

EMBL

AL009183 AY438976 BC006196 L12964 U03397

GenPept

AAA53133 AAA62478 AAH06196 AAR05440 CAB57398