InnateDB Protein
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IDBP-88295.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CNNM2
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Protein Name
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cyclin M2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358891
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InnateDB Gene
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IDBG-88291 (CNNM2)
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Protein Structure
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Function |
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
Hypomagnesemia 6 (HOMG6) [MIM:613882]: A renal disease characterized by severely lowered serum magnesium levels in the absence of other electrolyte disturbances. Affected individuals show an inappropriately normal urinary magnesium excretion, demonstrating a defect in tubular reabsorption. Age of clinical onset is highly variable and some affected individuals are asymptomatic. {ECO:0000269PubMed:21397062}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop. {ECO:0000269PubMed:21397062}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0030554
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adenyl nucleotide binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002550
Domain of unknown function DUF21
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PFAM |
PF01595
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H8M5
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PhosphoSite |
PhosphoSite-Q9H8M5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
54805
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UniGene |
Hs.743405
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RefSeq |
NP_951059
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HUGO |
HGNC:103
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OMIM |
607803
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CCDS |
CCDS7543
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HPRD |
07418
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IMGT |
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EMBL |
AF216962
AK000071
AK023066
AK023479
AL139817
AL356608
BC021222
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GenPept |
AAF86374
AAH21222
BAA90926
BAB14386
BAB14585
CAI16511
CAI16512
CAI16513
CAI40076
CAI40077
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