InnateDB Protein
|
IDBP-88343.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ERRFI1
|
Protein Name
|
ERBB receptor feedback inhibitor 1
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000366702
|
InnateDB Gene
|
IDBG-88341 (ERRFI1)
|
Protein Structure
|
|
Function |
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:7641805}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
28
[view]
|
Protein-Protein |
27
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006950
|
response to stress
|
GO:0007175
|
negative regulation of epidermal growth factor-activated receptor activity
|
GO:0031953
|
negative regulation of protein autophosphorylation
|
GO:0032321
|
positive regulation of Rho GTPase activity
|
GO:0042059
|
negative regulation of epidermal growth factor receptor signaling pathway
|
GO:0043589
|
skin morphogenesis
|
GO:0045616
|
regulation of keratinocyte differentiation
|
GO:0048286
|
lung alveolus development
|
GO:0060426
|
lung vasculature development
|
GO:0060428
|
lung epithelium development
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR015116
Cdc42 binding domain like
IPR021619
EGFR receptor inhibitor Mig-6
|
PFAM |
PF09027
PF11555
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9UJM3
|
PhosphoSite |
PhosphoSite-Q9UJM3
|
TrEMBL |
I6S2Y9
|
UniProt Splice Variant |
|
Entrez Gene |
54206
|
UniGene |
Hs.605445
|
RefSeq |
NP_061821
|
HUGO |
HGNC:18185
|
OMIM |
608069
|
CCDS |
CCDS94
|
HPRD |
09218
|
IMGT |
|
EMBL |
AJ276373
AK315718
AL034417
AL137274
BC025337
CH471130
JQ867454
|
GenPept |
AAH25337
AFM52327
BAG38076
CAB52551
CAB70672
CAC20426
EAW71593
EAW71594
|
|
|