InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENO1

Summary

InnateDB Protein

IDBP-88404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENO1

Protein Name

enolase 1, (alpha)

Synonyms

ENO1L1; MPB1; NNE; PPH;

Species

Homo sapiens

Ensembl Protein

ENSP00000234590

InnateDB Gene

IDBG-88402 (ENO1)

Protein Structure

UniProt Annotation

Function

Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10802057}. Cell membrane {ECO:0000269PubMed:10802057}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269PubMed:10802057}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.Isoform MBP-1: Nucleus.

Disease Associations

Tissue Specificity

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.

Experimentally validated
Total	78 [view]
Protein-Protein	78 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0004634	phosphopyruvate hydratase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006351	transcription, DNA-templated
GO:0009615	response to virus
GO:0030308	negative regulation of cell growth
GO:0044281	small molecule metabolic process
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0000015	phosphopyruvate hydratase complex
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031430	M band
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000941 Enolase
IPR020810 Enolase, C-terminal
IPR020811 Enolase, N-terminal
IPR029017 Enolase N-terminal domain-like
IPR029065 Enolase C-terminal domain-like

PFAM

PF00113
PF03952

PRINTS

PR00148

PIRSF

PIRSF001400

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt