Version 5.4
Homo sapiens Protein: PCGF6
Summary
InnateDB Protein IDBP-88411.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCGF6
Protein Name polycomb group ring finger 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000338845
InnateDB Gene IDBG-88407 (PCGF6)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269PubMed:12167161, ECO:0000269PubMed:17320162}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12167161, ECO:0000269PubMed:21282530}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
IPR029071 Ubiquitin-related domain
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BYE7
PhosphoSite PhosphoSite-Q9BYE7
TrEMBL
UniProt Splice Variant
Entrez Gene 84108
UniGene Hs.741474
RefSeq NP_115530
HUGO HGNC:21156
OMIM 607816
CCDS CCDS7546
HPRD 07427
IMGT
EMBL AB047006 AK027885 AK290679 AL591408 BC007602 BC010235
GenPept AAH07602 AAH10235 BAB40779 BAF83368 CAI16745 CAI16746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca