InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC2A5

Summary

InnateDB Protein

IDBP-88460.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC2A5

Protein Name

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

Synonyms

GLUT-5; GLUT5;

Species

Homo sapiens

Ensembl Protein

ENSP00000366631

InnateDB Gene

IDBG-88456 (SLC2A5)

Protein Structure

UniProt Annotation

Function

Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter.

Subcellular Localization

Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Membrane; Multi-pass membrane protein. Note=Localized on the apical membrane of the small intestine and the proximal tubule of the kidney. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0022857	transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0008645	hexose transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0071332	cellular response to fructose stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002442 Fructose transporter, type 5 (GLUT5)
IPR003663 Sugar/inositol transporter
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PR01194
PR00171

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P22732