InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDCD11

Summary

InnateDB Protein

IDBP-88495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD11

Protein Name

programmed cell death 11

Synonyms

ALG-4; ALG4; NFBP; RRP5;

Species

Homo sapiens

Ensembl Protein

ENSP00000358812

InnateDB Gene

IDBG-88493 (PDCD11)

Protein Structure

UniProt Annotation

Function

Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269PubMed:17654514}.Involved in the biogenesis of rRNA. {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:14624448, ECO:0000269PubMed:17654514}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006364	rRNA processing
GO:0006396	RNA processing
GO:0006397	mRNA processing

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000110 Ribosomal protein S1
IPR003029 Ribosomal protein S1, RNA-binding domain
IPR003107 HAT (Half-A-TPR) repeat
IPR008847 Suppressor of forked
IPR012340 Nucleic acid-binding, OB-fold
IPR013026 Tetratricopeptide repeat-containing domain
IPR022967 RNA-binding domain, S1

PFAM

PF00575
PF02184
PF05843

PRINTS

PR00681

PIRSF

PIRSF002111

SMART

SM00386
SM00316

TIGRFAMs

Post-translational Modifications

Modification

Cross-References