Homo sapiens Protein: SPSB1
Summary
InnateDB Protein IDBP-88511.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPSB1
Protein Name splA/ryanodine receptor domain and SOCS box containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000330221
InnateDB Gene IDBG-88509 (SPSB1)
Protein Structure
UniProt Annotation
Function Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269PubMed:15601820}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001496 SOCS protein, C-terminal
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF07525
PF00622
PRINTS
PIRSF
SMART SM00253
SM00969
SM00449
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96BD6
PhosphoSite PhosphoSite-Q96BD6
TrEMBL A2A276
UniProt Splice Variant
Entrez Gene 80176
UniGene Hs.8261
RefSeq NP_079382
HUGO HGNC:30628
OMIM 611657
CCDS CCDS102
HPRD 18106
IMGT
EMBL AB209559 AF403026 AK026046 AL008734 AL358252 BC005852 BC015711 CH471130
GenPept AAH05852 AAH15711 AAL57345 BAB15335 BAD92796 CAI14376 CAM12843 EAW71617 EAW71618