InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OBFC1

Summary

InnateDB Protein

IDBP-88643.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OBFC1

Protein Name

oligonucleotide/oligosaccharide-binding fold containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000224950

InnateDB Gene

IDBG-88641 (OBFC1)

Protein Structure

UniProt Annotation

Function

Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. {ECO:0000269PubMed:19648609, ECO:0000269PubMed:19854130}.

Subcellular Localization

Nucleus. Chromosome, telomere.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	37 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0043047	single-stranded telomeric DNA binding

Biological Process

GO:0000723	telomere maintenance
GO:0010833	telomere maintenance via telomere lengthening
GO:0045740	positive regulation of DNA replication

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0043231	intracellular membrane-bounded organelle
GO:0045111	intermediate filament cytoskeleton
GO:0070188	Stn1-Ten1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR012340 Nucleic acid-binding, OB-fold
IPR014647 CST complex subunit Stn1
IPR015253 CST complex subunit Stn1, C-terminal

PFAM

PF01336
PF09170

PRINTS

PIRSF

PIRSF036950

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H668