InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLSTN1

Summary

InnateDB Protein

IDBP-88650.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLSTN1

Protein Name

calsyntenin 1

Synonyms

ALC-ALPHA; alcalpha1; alcalpha2; CDHR12; CSTN1; PIK3CD; XB31alpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000354997

InnateDB Gene

IDBG-88646 (CLSTN1)

Protein Structure

UniProt Annotation

Function

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:17332754}; Single-pass type I membrane protein {ECO:0000269PubMed:17332754}. Golgi apparatus membrane {ECO:0000269PubMed:17332754}. Cell projection {ECO:0000269PubMed:17332754}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000269PubMed:17332754}. Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level). {ECO:0000269PubMed:12498782, ECO:0000269PubMed:12972431}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019894	kinesin binding
GO:0042988	X11-like protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0042995	cell projection
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome