InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLK

Summary

InnateDB Protein

IDBP-88665.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLK

Protein Name

STE20-like kinase

Synonyms

bA16H23.1; LOSK; se20-9; STK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000358770

InnateDB Gene

IDBG-88663 (SLK)

Protein Structure

UniProt Annotation

Function

Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. {ECO:0000269PubMed:10699464}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0023014	signal transduction by phosphorylation
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001943 UVR domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022165 Polo kinase kinase

PFAM

PF00069
PF07714
PF02151
PF12474

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt